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BACKGROUNDVascular endothelial growth factor (VEGF)–targeted therapies are standard treatment for metastatic renal cell carcinoma (mRCC); however, toxicities can lead to drug discontinuation, which can affect patient outcomes. This study was aimed at identifying risk factors for toxicity and constructing the first model to predict toxicity‐related treatment discontinuation (TrTD) in mRCC patients...
BACKGROUNDPatients with myeloproliferative neoplasms (MPNs) experience a high persistence, prevalence, and severity of fatigue. There is currently only limited information regarding factors that contribute to fatigue in patients with MPNs.
METHODSA 70‐item, Internet‐based survey regarding fatigue was developed by MPN investigators and patients/advocates and hosted by the Mayo Clinic Survey Research...
Patient‐reported outcomes (PROs) measure quality of life, symptoms, patient functioning, and patient perceptions of care; they are essential for gaining a full understanding of cancer care and the impact of cancer on people's lives. Repeatedly captured facility‐level and/or population‐level PROs (PRO surveillance) could play an important role in quality monitoring and improvement, benchmarking, advocacy,...
BACKGROUNDRacial/ethnic and socioeconomic disparities persist in part because our current understanding of the care provided to minority and disadvantaged populations is limited. The authors evaluated the quality of breast cancer care in 2 large states to understand the disparities experienced by African Americans, Hispanics, Asian/Pacific Islanders (APIs), and Medicaid enrollees and to prioritize...
BACKGROUNDThe exonic single‐nucleotide variant rs11762213 located in the MET oncogene has recently been identified as a prognostic marker in clear cell renal cell carcinoma (ccRCC). This finding was validated with The Cancer Genome Atlas (TCGA) cohort, and the biologic implications were explored.
METHODSThe genotype status for rs11762213 was available for 272 patients. Paired tumor‐normal data, genomic...
Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells that occurs in hereditary and sporadic clinical settings. Metastatic spread commonly occurs to cervical and mediastinal lymph nodes. MTC cells do not concentrate radioactive iodine and are not sensitive to hormonal manipulation, and therefore surgery is the most effective option for curative therapy, reduction...
BACKGROUNDGiven the costs of delivering care for men with prostate cancer remain poorly described, this article reports the results of time‐driven activity‐based costing (TDABC) for competing treatments of low‐risk prostate cancer.
METHODSProcess maps were developed for each phase of care from the initial urologic visit through 12 years of follow‐up for robotic‐assisted laparoscopic prostatectomy...
BACKGROUNDInformed consent for clinical research includes 2 components: informed consent documents (ICDs) and informed consent conversations (ICCs). Readability software has been used to help simplify the language of the ICD, but to the authors' knowledge is rarely used to assess the language used during the ICC, which may influence the quality of informed consent. The current analysis was performed...
BACKGROUNDLynch syndrome confers a hereditary predisposition to colorectal and other cancers. Universal tumor screening (UTS) for Lynch syndrome is recommended by several professional societies, but the implementation can be complex. This article describes the evaluation, process development, and initiation of Lynch syndrome UTS at a tertiary referral cancer center.
METHODSA multidisciplinary team...
BACKGROUNDAfter a pilot study on skin cancer screening was performed between 2003 and 2004 in Schleswig‐Holstein, Germany, the country implemented what to the authors' knowledge is the first nationwide skin cancer screening program in the world in 2008. The objective of the current study was to provide details regarding mortality trends in Schleswig‐Holstein and Germany in relation to the screening...
BACKGROUNDImproved survival for individuals with metastatic cancer accentuates the importance of employment for cancer survivors. A better understanding of how metastatic cancer affects employment is a necessary step toward the development of tools for assisting survivors in this important realm.
METHODSThe ECOG‐ACRIN Symptom Outcomes and Practice Patterns study was analyzed to investigate what factors...
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